Different Evolution of Inh ibitory and A ctivating Killer I mmunoglobulin Receptors (KIR) in Worldwide Human Populations

HLA class I molecules are ligands for natural killer cells’ inhibitory (KIR DL) and activating (KIR DS) receptors. KIR DL receptors have a greater avidity for HLA class I molecules than KIR DS receptors. Thus, there is a possibility that HLA molecules drive KIR receptor selection. We have used the percentage of individuals bearing the genes KIR 3DS1, 2DS1, 2DS2, 2DS3, 2DS4, 2DS5, 2DL1, 2DL2, 2DL3, 2DL5 and 3DL1 in relatively well defined populations to test whether there is a different way of relating worldwide populations between KIR DS and KIR DL molecules. We h ave use d A RLEQUIN, D ISPAN and V ISTA computer p rograms t o c onstruct d endrograms a nd correspondence analyses showing the genetic relationships among different human world populations. Analyses based on KIR DS or KIR haplotype B ge nes show that populations are re lated according to geography, l ike a good a nthropological m arker (i .e.: HLA or Y chromosome systems). The results based on KIR DL or KIR haplotype A genes do not show such a correlation. Results are discussed taking into account the linkage of both HLA and KIR systems to microbial diseases and the possible evolutionary shaping of both HLA and KIR receptors repertoire by pathogens.